Timed bromocriptine administration reduces body fat stores in obese subjects and hyperglycemia in type II diabetics.

Obese postmenopausal female volunteers were given timed daily oral dosages of bromocriptine, and tested for reduction of body fat stores. This dopamine agonist has been shown to reset circadian rhythms that are altered in obese animals and to reduce body fat levels in several animal models. The participants were instructed not to alter their existing exercise and eating behavior during treatment. Skinfold measurements were taken on 33 subjects as indices of body fat. The measurements (e.g., suprailiac) were reduced after six weeks by about 25%, which represents a reduction of 11.7% of the total body fat. These dramatic decreases in body fat, which are equivalent to that produced by severe caloric restriction, were accompanied by more modest reductions of body weight (2.5%), indicating a possible conservation of protein that is usually lost as a consequence of such caloric restriction. The effects of bromocriptine treatment on body fat and hyperglycemia were also examined in non-insulin dependent diabetics being treated with oral hypoglycemics (7 subjects) or insulin (7 subjects). Total body fat was reduced by 10.7% and 5.1% in diabetics on oral hypoglycemics and insulin, respectively, without any significant reductions in body weight. Hyperglycemia was reduced in most of the 15 diabetic subjects treated leading to euglycemia and even cessation of hypoglycemic drugs in 3 of the 7 subjects during 4-8 weeks of bromocriptine treatment. These findings support the hypothesis that obesity and type II diabetes may be treated effectively with bromocriptine when administered at the proper times and dosages.     

谈DBASEⅢ数组变量的设计与应用

本文提出混合类型数组的概念,将DBASEⅢ管理系统数据库转换成二维数组变量,解决了在DBASEⅢ中没有数组变量的缺陷。为通用管理程序的设计、不同类型数据的处理以及提高运行速度等,都带来很多方便。     

舟山朱家尖岛的海滨底栖无脊椎动物

根据1986～1987年逐月调查和1987年以来结合教学实习采集的朱家尖海滨底栖无脊椎动物资料,并参考前人对该岛的调查,叙述了朱家尖岛海滨底栖无脊椎动物10门257种,分析了生活潮区、栖息底质等,提出了该岛潮间带生物资源保护的建议。     

微机字处理软件CAI开发方法的研究

本文阐述了研究计算机软件ＣＡＩ开发方法学的意义，并介绍了字处理软件Ｗｏｒｄｓｔａｒ的教学软件的开发方法．     

实时实现MPEG2运动估计的DSP处理系统

本文根据ＭＰＥＧ２的图像标准与要求，利用若干大规模集成电路芯片，设计了实时实现活动图像运动估计的ＤＳＰ处理系统板，通过序列图像的测试，证明其工作正常，性能可靠，完全符合ＭＰＥＧ２的技术规范，从而为我国近期实现ＭＰＥＧ２的编解码系统、乃至ＨＤＴＶ实验系统在硬件方面打下了良好的基础。     

磁光光盘动态性能的研究

该文报道了所研制的具有AIN/TbFeCo/AIN/AI四层结构磁光光盘的动态性能测试结果.当记录信息位尺寸为1μm时,信息读出载噪比大于45dB,载噪比随盘片径向位置而异.文中根据测试结果,讨论了影响载噪比的诸因素.     

数据采集与光条图象细化新方法——用于三维计算机视觉系统

介绍了具有位置反馈信息旋转平台的图象数据采集方法,以及对采集到的图象进行智能化快速细化的新方法,使得在一周内的36幅图象做到边采集边细化,而且仅用40s时间。     

奥氏体-贝氏体复相组织形态的研究

在60Si2MnA钢等温淬火工艺和性能研究的基础上,用MEF-3型金相显微镜和JEM-200CX型透射电子显微镜对等温转变产物的组织形态进行了观察研究。并用Rigku D/maxⅢB型X-射线衍射仪测定了样品的残余奥氏体体积分数。实验结果表明,奥氏体-贝氏体复相组织强韧性好的原因在于含有一定数量的残余奥氏体和变态贝氏体组织,且贝氏作为无碳化物贝氏体。     

Short alanine-based peptides may form 3(10)-helices and not alpha-helices in aqueous solution.

Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + 4; ref. 9) and the next most common peptide helix, the 3(10)-helix10 (i-->i + 3 hydrogen-bonding). To address this problem we have designed single and doubly spin-labelled analogues of alanine-based peptides in which the nitroxide spin label forms an unbranched side chain extending from the sulphur atom of a cysteine residue. Here we report the circular dichroism, Fourier-transform infrared and electron-spin resonance spectra of these peptides under helix-forming conditions. The infrared absorbance gives an amide I' band with a frequency that is substantially different from that observed for alpha-helices. The electron-spin resonance spectra of doubly labelled helices show that the ranking of distances between side chains, around a single turn (residues 4-8), is inconsistent with an alpha-helical structure. Our experiments suggest that the more likely peptide geometry is a 3(10)-helix.